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Parkinson's disease

01-11-2018 | Parkinson's disease | News | Article

Dopamine to levodopa-carbidopa switch reduces impulse control disorders in PD

Switching from dopamine agonists to levodopa-carbidopa slow-release formulations reduces impulse control disorders in patients with Parkinson’s disease, shows a multicentre study.

Source:

J Neurol Neurosurg Psychiatry 2018; doi:10.1136/jnnp-2018-318942

J Neurol Neurosurg Psychiatry 2018; doi:10.1136/jnnp-2018-319375

04-10-2018 | Neurology | News | Article

Global burden of Parkinson’s disease is on the rise

The global burden of Parkinson’s disease has more than doubled over the past 26 years, show findings from the Global Burden of Disease Study 2016.

Source:

Lancet Neurol 2018; doi:10.1016/S1474-4422(18)30295-3

Lancet Neurol 2018; doi:10.1016/S1474-4422(18)30355-7

03-08-2018 | Parkinson's disease | News | Article

Apomorphine infusion reduces ‘off time’ in patients with Parkinson’s disease

Subcutaneous apomorphine infusion meaningfully reduces the time in which a patient’s medication is not working optimally and parkinsonian symptoms return, reports the placebo-controlled, multicentre TOLEDO trial.

Source:

Lancet Neurol 2018; doi:10.1016/S1474-4422(18)30239-4
Lancet Neurol 2018; doi:10.1016/S1474-4422(18)30284-9

27-07-2018 | Parkinson's disease | News | Article

Editor's pick

Occipital GABA levels reduced in Parkinson’s patients with visual hallucinations

Reduced levels of γ-aminobutyric acid in the primary visual cortex are linked to visual hallucinations in patients with Parkinson’s disease, study findings indicate.

Source:

Neurology 2018; doi:10.1212/WNL.0000000000006007
Neurology 2018; doi:10.1212/WNL.0000000000005985

15-02-2017 | Parkinson's disease | Main feed | Article

Blood-based NfL differentiates PD and parkinsonian disorders

A simple blood test for neurofilament light chain protein could help physicians distinguish atypical parkinsonian disorders from Parkinson’s disease, study findings show.

Source:

Neurology 2017; Advance online publication

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13-12-2016 | Parkinson's disease | News | Article

Editor's pick

Biochemical test shows promise for diagnosing Parkinson’s disease

Researchers have developed a biochemical test for diagnosing Parkinson’s disease using technology that detects misfolded α-synuclein oligomers in cerebrospinal fluid.

Source:

JAMA Neurol 2016; Advance online publication

23-11-2016 | Parkinson's disease | News | Article

Editor's pick

Biomarker combination predicts early Parkinson’s cognitive impairment risk

Adding cerebrospinal fluid assessment and dopamine transporter imaging data to age and clinical assessment improves cognitive impairment prediction in newly diagnosed patients with Parkinson’s disease, study findings indicate.

Source:

Lancet Neurol 2016; Advance online publication

25-10-2016 | Parkinson's disease | News | Article

News in brief

Inhaled levodopa may relieve ‘off’ motor symptoms

CVT-301, an inhaled powdered form of levodopa, may help relieve “off” motor fluctuations that occur between doses of standard oral levodopa, phase II findings indicate.

04-10-2016 | Parkinson's disease | News | Article

News in brief

Growing evidence of inflammatory role in Parkinson’s disease

A heightened pro-inflammatory cytokine profile has been found in patients with Parkinson’s disease, supporting clinical evidence that the condition is accompanied by an inflammatory response.

Source:

JAMA Neurol 2016; Advance online publication

12-07-2016 | Parkinson's disease | News | Article

Editor's pick

TBI linked to Parkinson’s disease in later life, but not dementia

Traumatic brain injury with loss of consciousness is associated with an increased risk for neurodegenerative conditions, but Alzheimer’s disease is not one of them, suggests research.

Source:

JAMA Neurol 2016; Advance online publication

24-06-2016 | Parkinson's disease | News | Article

News in brief

Potential increase in PD incidence reported

A study in Minnesota, USA, has found an increase in the incidence of parkinsonism and Parkinson’s disease over the past 30 years that may be related to the dramatic reduction in smoking behaviour in the second half of the 20th century or other lifestyle or environmental changes.

03-06-2016 | Parkinson's disease | News | Article

Motor subtypes of PD show different prognostic traits

The severity of postural instability and gait difficulty appears to be a useful indicator of Parkinson’s disease progression, researchers report.

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Neurology 2016; Advance online publication

16-05-2016 | Parkinson's disease | News | Article

Many biomarkers for PD fail to inform on progression

Longitudinal monitoring of 30 tests for marker candidates in early Parkinson’s disease has found that just 10 show significant changes commensurate with disease progression.

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Neurology 2016; Advance online publication

05-04-2016 | Parkinson's disease | News | Article

Biopsy detects αSyn in submandibular gland of IRBD patients

Submandibular gland biopsy can be used to identify α-synuclein aggregates, potentially offering not only a simple means of histologically confirming Parkinson’s disease but also a marker for the disease in patients with premotor manifestations, researchers report.

Source:

Lancet Neurol 2016; Advance online publication

25-03-2016 | Parkinson's disease | News | Article

Genetic syndrome may underlie some Parkinson’s cases

Rare deletions at chromosome 22q11.2 are present at an increased rate in patients with Parkinson’s disease, researchers report in The Lancet Neurology.

Source:

Lancet Neurol 2016; Advance online publication

24-03-2016 | Parkinson's disease | News | Article

Rosacea linked to Parkinson’s disease risk

Data from a nationwide study show that people with the skin condition rosacea are at an increased risk of later developing Parkinson’s disease.

Source:

JAMA Neurol 2016; Advance online publication

22-03-2016 | Parkinson's disease | News | Article

Warning of increased mortality risk for PD patients taking antipsychotics

Researchers have found a more than twofold increase in the risk of death among patients with Parkinson’s disease who take antipsychotics, particularly typical antipsychotics.

Source:

JAMA Neurol 2016; Advance online publication

05-02-2016 | Parkinson's disease | News | Article

Falls, fractures may precede Parkinson’s disease by decades

People who later develop Parkinson’s disease have an increased tendency to fall and injure themselves, being at particular risk of hip fracture, a study shows.

Source:

PLoS Med 2016; 13: e1001954

19-01-2016 | Parkinson's disease | News | Article

Editor's pick

Physiotherapy ‘should be targeted’ in Parkinson’s disease

Physical and occupational therapy does not deliver quality of life benefits for patients with mild to moderate Parkinson’s disease, a randomised trial shows.

Source:

JAMA Neurol 2015; Advance online publication

13-01-2016 | Parkinson's disease | News | Article

Editor's pick

Anticholinesterase offers a ‘steadying hand’ to PD patients

The dementia drug rivastigmine may reduce the risk of falls in patients with Parkinson’s disease by improving gait stability, findings from the phase II ReSponD trial show.

Source:

Lancet Neurol 2016; Advance online publication

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