Paediatric patients with triiodothyronine-predominant Graves' disease develop severe disease that needs increased doses of antithyroid drugs, a study shows.
Researchers report a dose–response relationship between body mass index and cardiovascular risk even in severely obese adolescents, making its assessment important to limit further disease progression.
Children with short stature benefit from receiving combined treatment with growth hormone and insulin-like growth factor-1, if they have low endogenous levels of the latter, a study shows.
Many children who require insulin treatment on diagnosis with Type 2 diabetes can be weaned off the medication, show findings from the run-in phase of the Treatment Options for Type 2 Diabetes in Adolescents and Youth study.
Spontaneous catch-up growth after birth in short children who were born small for gestational age is a negative predictor of their long-term response to growth hormone treatment, say researchers.
Levels of insulin autoantibodies and insulinoma-associated protein 2 autoantibodies predict the onset of diabetes in young children with islet autoimmunity, show findings from the TEDDY study.
Researchers have found that girls with central precocious puberty have similar metabolic and general health to other women when they reach young to middle adulthood.
Research shows that postprandial glucagon levels increase over time in children with newly diagnosed Type 1 diabetes, and are associated with worsening glycaemic control, suggesting an adjunctive treatment approach.
Most tumour types reported in adult patients with multiple endocrine neoplasia Type-1 can be found in children with the condition, although rarely before the age of 10 years, shows a large study.
Genetic determinants of insulin sensitivity are positively related to spontaneous growth and response to growth hormone treatment in children born small for gestational age, researchers have found.
Artificial pancreas systems significantly improve glycaemic control in adolescents and adults with Type 1 diabetes, shows a head-to-head trial of single- and dual-hormone systems versus a conventional insulin pump.
Researchers have found that a high proportion of children initially diagnosed with isolated growth hormone deficiency will progress to combined pituitary hormone deficiency.
Researchers report that heritable microduplications on chromosome Xq26.3 may underlie a “striking” form of gigantism with onset in late infancy, and reveal a candidate culprit gene.
Researchers recommend measuring inhibin B concentration in combination with basal luteinising hormone as a first-line test to discover the underlying cause of delayed puberty in boys.